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GD (Soman)
Pinacolyl methylphosphono-fluoridate; 1,2,2-trimethyl propyl
methyl-phosphonofluoridate
Soman is a family of volatile, liquid anticholinesterase nerve
agents. Soman reacts irreversibly with the enzyme cholinesterase (ChE), thereby
permitting a deleterious accumulation of acetylcholine at nerve endings, which can
lead to rapid death.
GD causes miosis, salivation, lachrymation, muscular twitching and
fasciculation, diarrhea, frequent urination, convulsions, coma, respiratory failure and
death.
These autonomic, central and somatic neuromuscular systems are
responsible for the lethal actions of GD.
LD50 values are: rhesus monkey, 7 mg/kg, s.c.; rabbit, 16
mg/kg19.
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