Molecular Formula: C2H6O2
Molecular Weight: 62.08

Synonyms: Athylenglykol (German); 1,2-Dihydroxyethane; 1,2-Ethandiol; 1,2-Ethanediol; Ethane-1,2-diol; Ethylene alcohol; Ethylene dihydrate; Ethylene glycol (ACGIH); Glycol alcohol; Lutrol-9; Macrogol 400 BPC; M.E.G.; Monoethylene glycol; NCI-C00920; Norkool; Tescol; Dowtherm SR 1; Ucar 17

Compound Class: Agricultural Chemical; Tumorigen; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Wiswesser Line Notation: Q2Q
Record Date: 199712

IRRITATION DATA:

Eye Rat 12 mg/m3/3D TXAPA9 16,646,1970

Skin Rabbit 555 mg open Mild UCDS** 7/21/1965

Eye Rabbit 500 mg/24H Mild 85JCAE -,205,1986

Eye Rabbit 100 mg/1H Mild NTIS** LMF-69

Eye Rabbit 12 mg/m3/3D TXAPA9 16,646,1970

Eye Rabbit 1440 mg/6H Moderate BUYRAI 31,25,1977

MUTATION DATA:

DNA inhibition Human Lymphocyte 320 mmol/L PNASA6 79,1171,1982

Cytogenetic analysis Rat Oral 1200 mg/kg TGANAK 19,436,1985

Mutation in mammalian somatic cells Mouse Lymphocyte 100 mmol/L PAACA3 21,74,1980

REPRODUCTIVE EFFECTS DATA:

Developmental Abnormalities: Skin and skin appendages; Developmental Abnormalities: Musculoskeletal system; Developmental Abnormalities: Blood and lymphatic systems Oral Rat TDLo 50 gm/kg 6-15D preg TXAPA9 81,113,1985

Fetotoxicity (except death); Developmental Abnormalities: Musculoskeletal system Oral Rat TDLo 8580 mg/kg 6-15D preg CHYCDW 20,289,1986

Developmental Abnormalities: Craniofacial; Developmental Abnormalities: Musculoskeletal system Oral Rat TDLo 12500 mg/kg 6-15D preg TJADAB 29(2),52A,1984

Uterus, cervix, vagina; Litter size; Fetotoxicity (except death) Oral Rat TDLo 25 gm/kg 6-15D preg NTIS** PB85-104594

Post-implantation mortality Oral Rat TDLo 50 gm/kg 6-15D preg NTIS** PB85-104594

Other effects on female; Developmental Abnormalities: Musculoskeletal system; Other developmental abnormalities Inhalation Rat TCLo 2500 mg/m3/6H 6-15D preg FAATDF 24,57,1995

Fetotoxicity (except death); Developmental Abnormalities: Musculoskeletal system Oral Mouse TDLo 7500 mg/kg 6-15D preg TXAPA9 81,113,1985

Developmental Abnormalities: Craniofacial; Developmental Abnormalities: Musculoskeletal system Oral Mouse TDLo 7500 mg/kg 6-15D preg TJADAB 29(2),52A,1984

Live birth index; Growth statistics; Delayed effects Oral Mouse TDLo 84 gm/kg 1-21D preg/21D post TOXID9 4,136,1984

Post-implantation mortality; Stillbirth; Live birth index Oral Mouse TDLo 88720 mg/kg 7-14D preg EVHPAZ 57,141,1984

Uterus, cervix, vagina; Pre-implantation mortality; Other measures of fertility Oral Mouse TDLo 15 gm/kg 6-15D preg NTIS** PB85-105385

Uterus, cervix, vagina; Other effects on female; Pre-implantation mortality Inhalation Mouse TCLo 1000 mg/m3/6H 6-15D preg FAATDF 24,57,1995

Post-implantation mortality; Fetotoxicity (except death); Sex ratio Inhalation Mouse TCLo 1000 mg/m3/6H 6-15D preg FAATDF 24,57,1995

Other effects on female; Pre-implantation mortality; Post-implantation mortality Inhalation Mouse TCLo 2100 mg/m3/6H 6-15D preg FAATDF 27,49,1995

Litter size; Fetotoxicity (except death); Developmental Abnormalities: Musculoskeletal system Inhalation Mouse TCLo 2100 mg/m3/6H 6-15D preg FAATDF 27,49,1995

Other effects on female Oral Rabbit TDLo 28 gm/kg 6-19D preg NTIS** PB91-211219

TOXICITY EFFECTS DATA:

Sensory change involving peripheral nerve; Ulceration or bleeding from small intestine; Renal function tests depressed Oral Man TDLo 15 gm/kg AEMED3 20,208,1991

Sensory change involving peripheral nerve; Renal function tests depressed Oral Man TDLo 1195 mg/kg AEMED3 20,208,1991

General anesthetic; Respiratory stimulation; Kidney, Ureter, Bladder--Other changes Oral Child TDLo 5500 mg/kg PGMJAO 52,598,1976

Convulsions or effect on seizure threshold; Coma; Hypermotility, diarrhea Oral Human LDLo 786 mg/kg EJTXAZ 9,373,1976

Headache; Nausea or vomiting; Liver--Other changes Oral Human LDLo 398 mg/kg SMEZA5 26(2),48,1983

Lacrimation; Cough; Lungs, Thorax, or Respiration--Other changes Inhalation Human TCLo 10000 mg/m3 AGGHAR 5,1,1933

Coma; Renal function tests depressed; Metabolic acidosis Oral Man TDLo 16 gm/kg HETOEA 9,317,1990

Somnolence (general depressed activity); Coma; Respiratory stimulation Intramuscular Rat LDLo 3300 mg/kg JPETAB 41,387,1931

Somnolence (general depressed activity); Excitement; Nausea or vomiting Unreported Rat LD50 13 gm/kg GISAAA 33(3),16,1968

Chronic pulmonary edema or congestion; Changes in both tubules and glomeruli; Changes in spleen Intraperitoneal Mouse LD50 5614 mg/kg FEPRA7 6,342,1947

Somnolence (general depressed activity); Excitement; Nausea or vomiting Unreported Mouse LD50 8050 mg/kg GISAAA 33(3),16,1968

Kidney, Ureter, Bladder--Other changes; Hypoglycemia Oral Dog LD50 5500 mg/kg RMVEAG 154,137,1978

Kidney, Ureter, Bladder--Other changes; Hypoglycemia Oral Cat LD50 1650 mg/kg RMVEAG 154,137,1978

Convulsions or effect on seizure threshold; Muscle weakness; Blood--Other changes Subcutaneous Cat LDLo 2 gm/kg AGGHAR 5,1,1933

Somnolence (general depressed activity); Tremor; Convulsions or effect on seizure threshold Intravenous Rabbit LDLo 5 gm/kg JPETAB 41,387,1931

Somnolence (general depressed activity); Coma; Respiratory stimulation Intramuscular Rabbit LDLo 5500 mg/kg JPETAB 41,387,1931

Somnolence (general depressed activity); Excitement; Nausea or vomiting Unreported Rabbit LD50 5017 mg/kg GISAAA 33(3),16,1968

Somnolence (general depressed activity); Gastrointestinal--Other changes; Kidney, Ureter, Bladder--Other changes Oral Guinea pig LD50 6610 mg/kg JIHTAB 23,259,1941

Somnolence (general depressed activity); Excitement; Nausea or vomiting Unreported Guinea pig LD50 11150 mg/kg GISAAA 33(3),16,1968

OTHER MULTIPLE DOSE EFFECTS DATA:

Fluid intake; Changes in tubules; Death in the "U" date type field; Oral Rat TDLo 438 gm/kg/2Y-C FCTXAV 3,229,1965

Changes in bladder weight; Changes in serum composition (e.g., TP, bilirubin, cholesterol); Changes in P; Oral Rat TDLo 85230 mg/kg/90D-C DCTODJ 13,43,1990

Changes in Ca; Changes in P; Phosphatases; Oral Rat TDLo 12 mL/kg/6D-I TXAPA9 39,543,1977

Changes in tubules; Changes in serum composition (e.g., TP, bilirubin, cholesterol); Dehydrogenases; Oral Rat TDLo 26150 mg/kg/10D-C DCTODJ 13,43,1990

Changes in brain weight; Urine volume decreased or anuria; Weight loss or decreased weight gain; Inhalation Rat TCLo 8400 ug/m3/24H/12W-C GISAAA 39(9),106,1974

Corneal damage; Death in the "U" date type field; Inhalation Rat TCLo 12 mg/m3/8H/90D-I TXAPA9 16,646,1970

Lungs, Thorax, or Respiration--Other changes; Liver function tests impaired; Changes in tubules; Inhalation Rat TCLo 1 mg/m3/32W-I TPKVAL 7,102,1965

Hepatitis (hepatocellular necrosis), zonal; Changes in tubules; Weight loss or decreased weight gain; Oral Mouse TDLo 546 gm/kg/13W-C NTPTR* NTP-TR-413,1993

Hepatitis (hepatocellular necrosis), zonal; Changes in tubules; Oral Mouse TDLo 1081 gm/kg/2Y-C NTPTR* NTP-TR-413,1993

Changes in tubules; Oral Monkey TDLo 5751 gm/kg/22W-I TXAPA9 15,624,1969

Corneal damage; Eye--Other; Death in the "U" date type field; Inhalation Rabbit TCLo 12 mg/m3/8H/90D-I TXAPA9 16,646,1970

REVIEWS:

ACGIH TLV-Not classifiable as a human carcinogen DTLVS* TLV/BEI,1997

ACGIH TLV-CL 100 mg/m3 DTLVS* TLV/BEI,1997

TOXICOLOGY REVIEW AJMEAZ 38,409,1965

TOXICOLOGY REVIEW FAATDF 13,747,1989

TOXICOLOGY REVIEW REPTED 8,99,1994

STANDARDS AND REGULATIONS:

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE REGISTRATION FEREAC 54,7740,1989

MSHA STANDARD-air TWA 10 mg/m3 (particulate) DTLWS* 3,19,1973

OEL-AUSTRALIA TWA 60 mg/m3;STEL 120 mg/m3 JAN 1993

OEL-BELGIUM STEL 50 ppm (127 mg/m3) JAN 1993

OEL-DENMARK STEL 50 ppm (130 mg/m3) JAN 1993

OEL-DENMARK TWA 10 mg/m3 JAN 1993

OEL-FINLAND TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993

OEL-FINLAND TWA 50 ppm (125 mg/m3);STEL 75 ppm (190 mg/m3) JAN 1993

OEL-FRANCE STEL 50 ppm (125 mg/m3) JAN 1993

OEL-HUNGARY STEL 50 mg/m3;Skin JAN 1993

OEL-THE NETHERLANDS TWA 10 mg/m3 JAN 1993

OEL-THE NETHERLANDS TWA 50 ppm (125 mg/m3) JAN 1993

OEL-RUSSIA STEL 5 mg/m3 JAN 1993

OEL-SWEDEN TWA 50 ppm (130 mg/m3);STEL 75 ppm (190 mg/m3) JAN 1993

OEL-SWITZERLAND TWA 1 mg/m3 JAN 1993

OEL-SWITZERLAND TWA 50 ppm (125 mg/m3) JAN 1993

OEL-UNITED KINGDOM TWA 10 mg/m3 JAN 1993

OEL-UNITED KINGDOM TWA 60 mg/m3;STEL 125 mg/m3 JAN 1993

OEL IN BULGARIA COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND SINGAPORE, VIETNAM check ACGIH TLV

NIOSH CRITERIA DOCUMENTS:

NOHS 1974: HZD 32385; NIS 308; TNF 69314; NOS 174; TNE 743782

NOES 1983: HZD 32385; NIS 340; TNF 102395; NOS 214; TNE 1511087; TFE 4 46607

NTP, NIOSH, EPA STATUS:

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; N crassa-aneuploidy

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9100;8EHQ-0892-9252

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, SEPTEMBER 1997

NIOSH Analytical Method, 1994: Ethylene glycol, 5500

NIOSH Analytical Method, 1996: Glycols, 5523

NTP Carcinogenesis Studies (feed);no evidence:mouse NTPTR* NTP-TR-413,93

IRRITATION EFFECTS JOURNAL REFERENCES:

BUYRAI Bulletin of Parenteral Drug Association. Philadelphia, PA V.1-31, 1946-77.

NTIS** National Technical Information Service. Springfield, VA 22161

Formerly U.S. Clearinghouse for Scientific & Technical Information. TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959-

UCDS** Union Carbide Data Sheet. Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817

85JCAE Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986

MUTATION EFFECTS JOURNAL REFERENCES:

PAACA3 Proceedings of the American Association for Cancer Research. Waverly Press, 428 E. Preston St., Baltimore, MD 21202 V.1- 1954-

PNASA6 Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418 V.1- 1915-

TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1- 1967-

REPRODUCTIVE EFFECTS JOURNAL REFERENCES:

CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China Beginning history not known.

EVHPAZ EHP, Environmental Health Perspectives. U.S. Government Printing Office, Supt of Documents, Washington, DC 20402 No.1- 1972-

FAATDF Fundamental and Applied Toxicology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1981-

NTIS** National Technical Information Service. Springfield, VA 22161 Formerly U.S. Clearinghouse for Scientific & Technical Information.

TJADAB Teratology, The International Journal of Abnormal Development. Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003 V.1- 1968-

TOXID9 Toxicologist. Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311 V.1- 1981-

TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959-

TOXICITY EFFECTS JOURNAL REFERENCES:

AEMED3 Annals of Emergency Medicine. American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038

AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. Berlin, Ger. V.1-18, 1930-61. For publisher information, see IAEHDW.

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium V.4- 1898-

BJIMAG British Journal of Industrial Medicine. British Medical Journal, Box 560B, Kennebunkport, ME 04046 V.1- 1944-

EJTXAZ European Journal of Toxicology and Environmental Hygiene. Paris, France V.7-9, 1974-76. For publisher information, see TOERD9.

FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. Bethesda, MD V.1-46, 1942-87.

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1- 1936-

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1-36, 1957-1992. For publisher information, see MTPEEI

HETOEA Human & Experimental Toxicology. Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK V.9- 1990-

JIHTAB Journal of Industrial Hygiene and Toxicology. Cambridge, MA V.18-31, 1936-49. For publisher information, see AEHLAU.

JPETAB Journal of Pharmacology and Experimental Therapeutics. Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202 V.1- 1909/10-

KRKRDT Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Izdatel'stvo Naukova Dumka, Kiev, USSR No.1- 1975-

NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.

National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015

PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Topeka, KS

PGMJAO Postgraduate Medical Journal. Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK V.1- 1925-

RMVEAG Recueil de Medecine Veterinaire. Masson Pub. USA, Inc., Year Book Medical Pub., 35 E. Wacker Dr., Chicago IL 60601 V.1- 1824-

SMEZA5 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1- 1958-

34ZIAG Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969

85DCAI Poisoning; Toxicology, Symptoms, Treatments, 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970

OTHER MULTIPLE DOSE EFFECTS JOURNAL REFERENCES:

DCTODJ Drug and Chemical Toxicology. Marcel Dekker, 270 Madison Ave., New York, NY 10016 V.1- 1977/78-

FCTXAV Food and Cosmetics Toxicology. London, UK V.1-19, 1963-81. For publisher information, see FCTOD7.

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1- 1936-

NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206-

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.

Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Izdatel'stvo Meditsina, Moscow, USSR No.1- 1961- TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959-

REVIEWS JOURNAL REFERENCES:

AJMEAZ American Journal of Medicine. Technical Pub., 875 Third Ave., New York, NY 10022 V.1- 1946-

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996

FAATDF Fundamental and Applied Toxicology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1981-

REPTED Reproductive Toxicology. Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523 V.1- 1987

STANDARDS & REGULATIONS JOURNAL REFERENCES:

DTLWS* Documentation of the Threshold Limit Values for Substances in Workroom Air, Supplements. For publisher information, see 85INA8.

FEREAC Federal Register. U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402 V.1- 1936-

NTP, NIOSH, EPA STATUS JOURNAL REFERENCES:

NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206-

DATA PRESENT: Irritation Effects; Mutation Effects; Reproductive Effects; Toxicity Effects; Human Toxicity Effects; Other Multiple Dose Effects; Reviews; Standards and Regulations; NIOSH Criteria Documents; NTP, NIOSH, EPA Status