Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride

CAS Registry Number: 136-47-0
Substance Name: Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride

Molecular Formula: C15H24N2O2.ClH
Molecular Weight: 300.87

Synonyms: Amethocaine hydrochloride; Anacel; Anethaine; Butethanol; p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester, hydrochloride; p-Butylaminobenzoyl-2-dimethylaminoethanol hydrochloride; Butylocaine; Curtacain; Decicaine; Decicain; Dicaine hydrochloride; Dikain hydrochloride; Dimethylaminoethyl-p-N-butylaminobenzoate hydrochloride; 2-Dimethylaminoethanol 4-N-butylaminobenzoate hydrochloride; 2-(Dimethylamino)ethyl p-(butylamino)benzoate hydrochloride; Gingicain M; Menonasal; Pantocaine hydrochloride; Pontocaine hydrochloride; Sterile tetracaine hydrochloride; Tetracaine hydrochloride; Tonexol

Compound Class: Drug; Mutagen; Primary Irritant
Wiswesser Line Notation: 4MR DVO2N1&1 &GH
Record Date: 199606

IRRITATION DATA:

Eye Rabbit 2 % Moderate ARZNAD 8,181,1958

TOXICITY EFFECTS DATA:

Ataxia; Dyspnea; Respiratory depression Intraperitoneal Rat LD50 23500 ug/kg OYYAA2 9,413,1975

Ataxia; Dyspnea; Respiratory depression Subcutaneous Rat LD50 24 mg/kg OYYAA2 9,413,1975

Convulsions or effect on seizure threshold; Muscle weakness; Dyspnea Intravenous Rat LD50 4500 ug/kg OYYAA2 9,413,1975

Muscle weakness; Respiratory depression; Lungs, Thorax, or Respiration--Other changes Oral Mouse LD50 160 mg/kg OYYAA2 9,413,1975

  • Intraperitoneal Mouse LD50 23 mg/kg ARPMAS 321,115,1988
  • Subcutaneous Mouse LD50 25 mg/kg PHTXA6 22,138,1959

Convulsions or effect on seizure threshold; Muscle weakness; Dyspnea Intravenous Mouse LD50 6600 ug/kg OYYAA2 9,413,1975

  • Subcutaneous Rabbit LD50 15 mg/kg JPETAB 93,388,1948
  • Intravenous Rabbit LD50 2150 ug/kg NIIRDN 6,490,1982

Altered sleep time; Convulsions or effect on seizure threshold

Intratracheal Rabbit LD50 4400 ug/kg JPETAB 132,87,1961

  • Intraspinal Rabbit LDLo 5 mg/kg JPETAB 57,221,1936
  • Subcutaneous Guinea pig LD50 19500 ug/kg QJPPAL 20,380,1947
  • Intravenous Guinea pig LD50 4 mg/kg ARZNAD 7,739,1957

STANDARDS AND REGULATIONS:

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE REGISTRATION FEREAC 54,7740,1989

NIOSH CRITERIA DOCUMENTS:

NOHS 1974: HZD 81540; NIS 6; TNF 528; NOS 5; TNE 14149

NOES 1983: HZD 81540; NIS 3; TNF 1008; NOS 16; TNE 67099; TFE 55783

NTP, NIOSH, EPA STATUS: EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

IRRITATION EFFECTS JOURNAL REFERENCES:

ARZNAD Arzneimittel-Forschung. Drug Research. Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger. V.1- 1951-

TOXICITY EFFECTS JOURNAL REFERENCES:

ARPMAS Archiv der Pharmazie (Weinheim, Germany) VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441 V.51-261, 1835-1923; V.305- 1972-

ARZNAD Arzneimittel-Forschung. Drug Research. Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger. V.1- 1951-

JPETAB Journal of Pharmacology and Experimental Therapeutics. Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202 V.1- 1909/10-

NIIRDN Drugs in Japan (Ethical Drugs). Yakugyo Jiho Co., Ltd., Tokyo, Japan

OYYAA2 Oyo Yakuri. Pharmacometrics. Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan V.1- 1967-

PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. New York, NY V.20-22, 1957-59. Discontinued.

QJPPAL Quarterly Journal of Pharmacy & Pharmacology. London, UK V.2-21, 1929-48. For publisher information, see JPPMAB.

STANDARDS & REGULATIONS JOURNAL REFERENCES:

FEREAC Federal Register. U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402 V.1- 1936-

DATA PRESENT: Irritation Effects; Toxicity Effects; Standards and Regulations; NIOSH Criteria Documents; NTP, NIOSH, EPA Status

 
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