Molecular Formula: C7H16
Molecular Weight: 100.23

Synonyms: Dipropyl methane; Eptani (Italian); Gettysolve-C; Heptan (Polish); n-Heptane; Heptane (ACGIH:DOT:OSHA); Heptanen (Dutch); n-Heptane (OSHA); Heptyl hydride; UN1206 (DOT)

Compound Class: Drug; Human Data
Wiswesser Line Notation: 7H
Record Date: 199712

TOXICITY EFFECTS DATA:

Hallucinations, distorted perceptions Inhalation Human TCLo 1000 ppm/6M BMRII* 2979,-,1929

Convulsions or effect on seizure threshold Inhalation Mouse LCLo 59 gm/m3/41M BIZEA2 115,235,1921

OTHER MULTIPLE DOSE EFFECTS DATA:

Changes in liver weight; Oral Rat TDLo 60 gm/kg/3W-I NTIS** OTS0571116

Changes in bladder weight; Hypoglycemia; Weight loss or decreased weight gain; Oral Rat TDLo 260 gm/kg/13W-I NTIS** OTS0571116

Recordings from specific areas of CNS; Change in cochlear structure or function; Weight loss or decreased weight gain; Inhalation Rat TCLo 4000 ppm/6H/28D-I PHTOEH 76,41,1995

Liver--Other changes; Changes in serum composition (e.g., TP, bilirubin, cholesterol); Multiple enzyme effects; Intraperitoneal Rat TDLo 9625 mg/kg/7D-I TOLED5 14,169,1982

Liver--Other changes; Phosphatases; Hepatic microsomal mixed oxidase; Intraperitoneal Rat TDLo 8840 mg/kg/45D-I JJATDK 8,81,1988

REVIEWS:

ACGIH TLV-STEL 2050 mg/m3 (500 ppm) DTLVS* TLV/BEI,1997

ACGIH TLV-TWA 1640 mg/m3 (400 ppm) DTLVS* TLV/BEI,1997

STANDARDS AND REGULATIONS:

DOT-HAZARD 3; LABEL:FLAMMABLE LIQUID CFRGBR 49,172.101,1992

MSHA STANDARD-air TWA 500 ppm (2000 mg/m3) DTLVS* 3,124,1971

OSHA PEL (Gen Indu) 8H TWA 500 ppm (2000 mg/m3) CFRGBR 29,1910.1000,1994

OSHA PEL (Construc) 8H TWA 500 ppm (2000 mg/m3) CFRGBR 29,1926.55,1994

OSHA PEL (Shipyard) 8H TWA 500 ppm (2000 mg/m3) CFRGBR 29,1915.1000,1993

OSHA PEL (Fed Cont) 8H TWA 500 ppm (2000 mg/m3) CFRGBR 41,50-204.50,1994

OEL-AUSTRALIA TWA 400 ppm (1600 mg/m3);STEL 500 ppm (2000 mg/m3) JAN 1993

OEL-BELGIUM TWA 400 ppm (1640 mg/m3);STEL 500 ppm (2050 mg/m3) JAN 1993

OEL-DENMARK TWA 400 ppm (1600 mg/m3) JAN 1993

OEL-FINLAND TWA 300 ppm (1200 mg/m3);STEL 500 ppm (2000 mg/m3) JAN 199 

OEL-FRANCE TWA 400 ppm (1600 mg/m3) JAN 1993

OEL-GERMANY TWA 500 ppm (2000 mg/m3) JAN 1993

OEL-JAPAN TWA 200 ppm (820 mg/m3) JAN 1993

OEL-THE NETHERLANDS TWA 400 ppm (1600 mg/m3) JAN 1993

OEL-THE PHILIPPINES TWA 500 ppm (2000 mg/m3) JAN 1993

OEL-POLAND TWA 200 mg/m3 JAN 1993

OEL-RUSSIA TWA 200 ppm JAN 1993

OEL-SWEDEN TWA 200 ppm (800 mg/m3);STEL 300 ppm (1250 mg/m3) JAN 1993

OEL-SWITZERLAND TWA 400 ppm (1600 mg/m3);STEL 800 ppm JAN 1993

OEL-TURKEY TWA 500 ppm (2000 mg/m3) JAN 1993

OEL-UNITED KINGDOM TWA 400 ppm (1600 mg/m3);STEL 500 ppm JAN 1993

OEL IN BULGARIA COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND SINGAPORE, VIETNAM check ACGIH TLV

NIOSH CRITERIA DOCUMENTS:

NIOSH REL TO HEPTANE air:10H TWA 85 ppm;CL 440 ppm/15M NIOSH* DHHS #92-100,1992

NOHS 1974: HZD 36060; NIS 153; TNF 20154; NOS 110; TNE 221101

NOES 1983: HZD 36060; NIS 191; TNF 37852; NOS 134; TNE 449487; TFE 445 50

NTP, NIOSH, EPA STATUS:

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, SEPTEMBER 1997

NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500 NIOSH Analytical Method, 1996: Volatile organic compound, 2549

TOXICITY EFFECTS JOURNAL REFERENCES:

BIZEA2 Biochemische Zeitschrift. Berlin, Ger. V.1-346, 1906-67. For publisher information, see EJBCAI.

BMRII* U.S. Bureau of Mines Report of Investigation No. 2979, Patty, F.A., and W.P. Yant, 1929

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1-36, 1957-1992. For publisher information, see MTPEEI

JPMSAE Journal of Pharmaceutical Sciences. American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037 V.50- 1961-

OTHER MULTIPLE DOSE EFFECTS JOURNAL REFERENCES:

JJATDK JAT, Journal of Applied Toxicology. John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK V.1- 1981-

NTIS** National Technical Information Service. Springfield, VA 22161 Formerly U.S. Clearinghouse for Scientific & Technical Information.

PHTOEH Pharmacology and Toxicology (Copenhagen). Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark V.60- 1987-

TOLED5 Toxicology Letters. Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands V.1- 1977-

REVIEWS JOURNAL REFERENCES:

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996

STANDARDS & REGULATIONS JOURNAL REFERENCES:

CFRGBR Code of Federal Regulations. U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996

DATA PRESENT: Toxicity Effects; Human Toxicity Effects; Other Multiple Dose Effects; Reviews; Standards and Regulations; NIOSH Criteria Documents; NTP, NIOSH, EPA Status