HCFC 141b

CAS Registry Number: 1717-00-6
Substance Name: HCFC 141b

Molecular Formula: C2H3Cl2F
Molecular Weight: 116.95 Beilstein Registry Number: 1731585
Beilstein Source Citation: 4-01-00-00134

Synonyms: CFC 141b; 1,1-Dichloro-1-fluoroethane; HCFC 141b; Isotron 141b; R 141b; Refrigerant 141b; Solkane 141b

Compound Class: Mutagen; Reproductive Effector
Record Date: 199710

MUTATION DATA:

Cytogenetic analysis Hamster Ovary 10 pph/4H-C FCTOD7 33,491,1995

REPRODUCTIVE EFFECTS DATA:

Post-implantation mortality;Litter size;Fetotoxicity (except death) Inhalation Rat TCLo 20000 ppm/6H 6-15D preg FCTOD7 33,285,1995

Fetal death Inhalation Rat TCLo 20000 ppm/6H 6-15D preg FCTOD7 33,285,1995

TOXICITY EFFECTS DATA:

  • Oral Rat LD50 >5 gm/kg FCTOD7 33,483,1995 Tremor;Ataxia Inhalation Rat LC50 56700 ppm/6H FCTOD7 33,483,1995 Liver--Other changes Skin Rat LD50 >2 gm/kg FCTOD7 33,483,1995

General anesthetic;Ataxia;Cyanosis Inhalation Mouse LC50 151 gm/m3/2H GTPZAB 9(10),37,1965

  • Skin Rabbit LD50 >2 gm/kg FCTOD7 33,483,1995

OTHER MULTIPLE DOSE EFFECTS DATA:

Evidence of thyroid hypofunction; Inhalation Rat TCLo 50 gm/m3/4H/4W-I TPKVAL 9,175,1967

BP lowering not characterized in autonomic section; Proteinuria; Phosphatases; Inhalation Rat TCLo 18200 mg/m3/4H/26W-I TPKVAL 8,83,1966

Changes in leukocyte (WBC) count; Inhalation Guinea pig TCLo 18200 mg/m3/4H/26W-I TPKVAL 8,83,1966

NTP, NIOSH, EPA STATUS:

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, SEPTEMBER 1997

MUTATION EFFECTS JOURNAL REFERENCES:

FCTOD7 Food and Chemical Toxicology. Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523 V.20- 1982-

REPRODUCTIVE EFFECTS JOURNAL REFERENCES:

FCTOD7 Food and Chemical Toxicology. Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523 V.20- 1982-

TOXICITY EFFECTS JOURNAL REFERENCES:

FCTOD7 Food and Chemical Toxicology. Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523 V.20- 1982-

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1-36, 1957-1992. For publisher information, see MTPEEI

OTHER MULTIPLE DOSE EFFECTS JOURNAL REFERENCES:

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Izdatel'stvo Meditsina, Moscow, USSR No.1- 1961-

DATA PRESENT: Mutation Effects; Reproductive Effects; Toxicity Effects; Other Multiple Dose Effects; NTP, NIOSH, EPA Status

 

 
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