Carbon tetrachloride

CAS Registry Number: 56-23-5
Substance Name: Carbon tetrachloride

Molecular Formula: CCl4 Molecular Weight: 153.81

Synonyms: Benzinoform; Carbona; Carbon chloride (CCl4); Carbon TET; Carbon tetrachloride (ACGIH:DOT:OSHA); Chlorid uhlicity (Czech); Czterochlorek wegla (Polish); ENT 4,705; ENT 27164; Flukoids; Halon 1040; Methane tetrachloride; Methane, tetrachloro-; Necatorina; Perchloromethane; R 10; RCRA waste number U211; R 10 (Refrigerant); Tetrachloorkoolstof (Dutch); Tetrachloormetaan; Tetrachlorkohlenstoff, tetra (German); Tetrachlormethan (German); Tetrachlorocarbon; Tetrachloromethane (OSHA); Tetrachlorure de carbone (French); Tetraclorometano (Italian); Tetracloruro di carbonio (Italian); Tetrafinol; Tetraform; Tetrasol; UN1846 (DOT); Univerm; Vermoestricid

Compound Class: Agricultural Chemical; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant Wiswesser Line Notation: GXGGG
Record Date: 199712

IRRITATION DATA:
Skin Rabbit 4 mg Mild XEURAQ MDDC-1715
Skin Rabbit 500 mg/24H Mild 85JCAE -,91,1986
Eye Rabbit 2200 ug/30S Mild XEURAQ MDDC-1715
Eye Rabbit 500 mg/24H Mild 85JCAE -,91,1986

MUTATION DATA:
Mutation in microorganisms Salmonella typhimurium 20 uL/L EJMBA2 18,213,1983

DNA repair Escherichia coli 12500 ng/well MUREAV 133,161,1984

DNA adduct Escherichia coli 300 ppm MUREAV 89,95,1981

Phage inhibition capacity Escherichia coli 200 ug/well MUREAV 260,349,1991

Mutation in microorganisms Aspergillus nidulans 5000 ppm MUREAV 147,288,1985

Gene conversion and mitotic recombination Aspergillus nidulans 5000 ppm MUREAV 147,288,1985

Sex chromosome loss and nondisjunction Aspergillus nidulans 5000 ppm MUREAV 147,288,1985

DNA adduct Rat Intraperitoneal 367 umol/kg IJCNAW 11,419,1973

DNA damage Rat Subcutaneous 31 gm/kg/12W-I FHCYAI 13,207,1975

DNA damage Rat Liver 3 mmol/L SinJF# 26OCT1982

Other mutation test systems Rat Intraperitoneal 100 mg/kg TOLED5 35,191,1987

Unscheduled DNA synthesis Rat Intraperitoneal 100 mg/kg TOLED5 35,191,1987

Unscheduled DNA synthesis Rat Oral 1400 mg/kg MUREAV 320,189,1994

Other mutation test systems Rat Oral 50 mg/kg MUREAV 344,109,1995

Cytogenetic analysis Rat Subcutaneous 31 gm/kg/12W-I FHCYAI 13,207,1975

DNA adduct Mouse Intraperitoneal 367 umol/kg IJCNAW 11,419,1973

DNA adduct Mouse Liver 10 umol PAACA3 24,81,1983

DNA damage Mouse Oral 335 umol/kg PSEBAA 175,237,1984

DNA damage Mouse Lymphocyte 6550 umol/L MUREAV 203,155,1988

Unscheduled DNA synthesis Mouse Oral 100 mg/kg ENMUDM 6,474,1984

DNA inhibition Mouse Oral 2 gm/kg MUREAV 46,305,1977

Morphological transformation Hamster Embryo 500 ug/L CRNGDP 4,291,1983

Sex chromosome loss and nondisjunction Hamster Lung 1600 umol/L MUREAV 182,135,1987

DNA adduct Mammal (species unspecified) Lymphocyte 1 mmol/L TOLED5 11,243,1982

REPRODUCTIVE EFFECTS DATA:

Post-implantation mortality Oral Rat TDLo 2 gm/kg 7-8D preg 85DJA5 -,95,1971

Extra embryonic structures Oral Rat TDLo 3 gm/kg 14D preg BEXBAN 82,1262,1976

Fetotoxicity (except death);Developmental Abnormalities: Musculoskeletal system;Developmental Abnormalities: Homeostasis Inhalation Rat TCLo 300 ppm/7H 6-15D preg TXAPA9 28,452,1974

Viability index;Weaning or lactation index Inhalation Rat TCLo 250 ppm/8H 10-15D preg DABBBA 32,2021,1971

Testes, epididymis, sperm duct;Prostate, seminal vessicle, Cowper's gland, accessory glands Intraperitoneal Rat TDLo 71500 mg/kg 15D male EXPEAM 22,395,1966

Other effects on male Intraperitoneal Rat TDLo 5 gm/kg 1D male TXCYAC 10,39,1978

Fetotoxicity (except death);Developmental Abnormalities: Hepatobiliary system Parenteral Rat TDLo 2384 mg/kg 18D preg BEXBAN 76,1467,1973

TUMORIGENIC EFFECTS DATA:

Equivocal tumorigenic agent criteria; Liver--Tumors; Subcutaneous Rat TDLo 15600 mg/kg/12W-I JNCIAM 38,891,1967

Neoplastic criteria; Liver--Tumors; Skin and appendages--Tumors; Oral Mouse TDLo 4400 mg/kg/19W-I JNCIAM 20,431,1958

Equivocal tumorigenic agent criteria; Liver--Tumors; Parenteral Mouse TDLo 305 gm/kg/30W-I BEXBAN 89,845,1980

Equivocal tumorigenic agent criteria; Hepatitis, fibrous (cirrhosis, post-necrotic scarring); Liver--Tumors; Oral Hamster TDLo 9250 mg/kg/30W-I JNCIAM 26,855,1961

Neoplastic criteria; Liver--Tumors; Oral Mouse TD 12 gm/kg/88D-I JNCIAM 4,385,1944

Equivocal tumorigenic agent criteria; Liver--Tumors; Subcutaneous Rat TD 100 gm/kg/25W-I KRMJAC 12,37,1965

Equivocal tumorigenic agent criteria; Liver--Tumors; Subcutaneous Rat TD 31 gm/kg/12W-I JNCIAM 45,1237,1970

Carcinogenic criteria; Liver--Tumors; Thyroid tumors; Subcutaneous Rat TD 182 gm/kg/70W-I JNCIAM 44,419,1970

Neoplastic criteria; Liver--Tumors; Oral Mouse TD 8580 mg/kg/9W-I JNCIAM 4,385,1944

Neoplastic criteria; Liver--Tumors; Oral Mouse TD 57600 mg/kg/12W-I JNCIAM 2,197,1941

TOXICITY EFFECTS DATA:

Nausea or vomiting Inhalation Human TCLo 20 ppm 85CYAB 2,136,1959 Miosis (pupillary constriction);Coma;Antipsychotic Oral Woman TDLo 1800 mg/kg TXMDAX 69,86,1973

Tremor;Lungs, Thorax, or Respiration--Other changes;Gastrointestinal--Other changes Oral Man TDLo 1700 mg/kg SAMJAF 49,635,1975

Change in rate;Cyanosis;Interstitial nephritis Oral Man LDLo 429 mg/kg ZHYGAM 19,781,1973

Inhalation Human LCLo 1000 ppm PCOC** -,198,1966

Somnolence (general depressed activity);Anorexia (human);Nausea or vomiting Inhalation Human TCLo 45 ppm/3D LANCAO 1,360,1960

Nausea or vomiting Inhalation Human TCLo 317 ppm/30M JAMAAP 103,962,1934

Inhalation Human LCLo 5 pph/5M TABIA2 3,231,1933

Unreported Man LDLo 93 mg/kg 85DCAI 2,73,1970

Oral Rat LD50 2350 mg/kg ARTODN 54,275,1983

Inhalation Rat LC50 8000 ppm/4H NPIRI* 1,16,1974

Skin Rat LD50 5070 mg/kg SPEADM 78-1,16,1978

Intraperitoneal Rat LD50 1500 uL/kg XEURAQ MDDC-1715

Intratracheal Rat LDLo 90 mg/kg NTIS** OTS0520615

Oral Mouse LD50 8263 mg/kg JPPMAB 3,169,1951

Inhalation Mouse LC50 9526 ppm/8H JIHTAB 29,382,1947

Intraperitoneal Mouse LD50 572 mg/kg PHMCAA 10,172,1968

Sleep;Ataxia Subcutaneous Mouse LD50 31 gm/kg JPETAB 123,224,1958

Oral Dog LDLo 1 gm/kg QJPPAL 7,205,1934

General anesthetic;BP lowering not characterized in autonomic section;Body temperature decrease Inhalation Dog LCLo 14620 ppm/8H NIHBAZ 191,1,1949

Liver function tests impaired Intraperitoneal Dog LD50 1500 mg/kg TXAPA9 10,119,1967

Intravenous Dog LDLo 125 mg/kg QJPPAL 7,205,1934

Inhalation Cat LCLo 38110 ppm/2H HBAMAK 4,1405,1935

Lungs, Thorax, or Respiration--Other changes;Fatty liver degeneration;Hemorrhage Subcutaneous Cat LDLo 300 mg/kg JPETAB 63,153,1938

Oral Rabbit LD50 5760 mg/kg GISAAA 33(1),32,1968

Skin Rabbit LD50 >20 gm/kg ATDAEI 1,712,1992

Intraperitoneal Rabbit LDLo 477 mg/kg GASTAB 71,118,1976

Subcutaneous Rabbit LDLo 3 gm/kg QJPPAL 7,205,1934

Excitement;Coma;Dyspnea Intravenous Rabbit LD50 5840 mg/kg

ZAPPAN 118,305,1974

Oral Guinea pig LD50 5760 mg/kg GISAAA 33(1),32,1968

Inhalation Guinea pig LCLo 20000 ppm/2H FLCRAP 1,197,1967

Skin Guinea pig LD50 >9400 uL/kg TXAPA9 7,559,1965

Ulceration or bleeding from small intestine;Gastrointestinal--Other changes Intraperitoneal Chicken LD50 4497 mg/kg BVJOA9 127,304,1971

Inhalation Frog LCLo 58 gm/m3 AEXPBL 97,86,1923

Oral Mammal (species unspecified) LD50 6 gm/kg GTPZAB 32(10),25,1988

Inhalation Mammal (species unspecified) LC50 34500 mg/m3 GTPZAB 24(3),17,1980

OTHER MULTIPLE DOSE EFFECTS DATA:

Changes in liver weight; Hepatic microsomal mixed oxidase; Transaminases; Oral Rat TDLo 1200 mg/kg/12W-I FAATDF 15,558,1990

Liver--Other changes; Oral Rat TDLo 4197 ug/kg/28D-I JPPMAB 3,169,1951

Changes in liver weight; Weight loss or decreased weight gain; Transaminases; Oral Rat TDLo 400 mg/kg/10D-I FAATDF 17,186,1991

Evidence of thyroid hypofunction; Inhalation Rat TCLo 41 mg/m3/4H/8D-I TPKVAL 12,5,1971

Fatty liver degeneration; Liver--Other changes; Inhalation Rat TCLo 61 mg/m3/90D-C TXAPA9 10,270,1967

Changes in liver weight; Inhalation Rat TCLo 400 ppm/1H/46D-I AMIHBC 6,50,1952

Hepatitis (hepatocellular necrosis), zonal; Fatty liver degeneration; Death in the "U" date type field; Inhalation Rat TCLo 200 ppm/7H/27W-I AMIHBC 6,50,1952

Fatty liver degeneration; Inhalation Rat TCLo 50 ppm/3H/8W-I INHEAO 11,48,1973

Structural change in nerve or sheath; Death in the "U" date type field; Inhalation Rat TCLo 400 ppm/8H/46W-I JIHTAB 18,277,1936

Hepatitis, fibrous (cirrhosis, post-necrotic scarring); Subcutaneous Rat TDLo 31200 uL/kg/12W-I ARPAAQ 85,275,1968

Changes in liver weight; Changes in Spleen weight; Death in the "U" date type field; Oral Mouse TDLo 8750 mg/kg/14D-I FAATDF 7,454,1986

Changes in liver weight; Changes in Spleen weight; Phosphatases; Oral Mouse TDLo 1080 mg/kg/90D-I FAATDF 7,454,1986

Muscle weakness; Change in clotting factors; Death in the "U" date type field; Oral Dog TDLo 636 gm/kg/16D-I JPETAB 22,215,1923

Fatty liver degeneration; Inhalation Dog TCLo 515 mg/m3/8H/6W-I TXAPA9 10,270,1967

Fibrosis, interstitial; Weight loss or decreased weight gain; Death in the "U" date type field; Inhalation Monkey TCLo 515 mg/m3/8H/6W-I TXAPA9 10,270,1967

Liver--Other changes; Hair; Inhalation Monkey TCLo 61 mg/m3/90D-C TXAPA9 10,270,1967

Structural change in nerve or sheath; Inhalation Monkey TCLo 200 ppm/8H/46W-I JIHTAB 18,277,1936

Fatty liver degeneration; Inhalation Rabbit TCLo 515 mg/m3/8H/6W-I TXAPA9 10,270,1967

Liver--Other changes; Inhalation Rabbit TCLo 61 mg/m3/90D-C TXAPA9 10,270,1967

Weight loss or decreased weight gain; Inhalation Rabbit TCLo 100 ppm/7H/30W-I AMIHBC 6,50,1952

Liver function tests impaired; Other changes in urine composition; Decreased immune response; Inhalation Rabbit TCLo 100 mg/m3/3H/35W-I GTPZAB 25(5),47,1981

Fatty liver degeneration; Weight loss or decreased weight gain; Death in the "U" date type field; Inhalation Guinea pig TCLo 515 mg/m3/8H/6W-I TXAPA9 10,270,1967

Fatty liver degeneration; Weight loss or decreased weight gain; Death in the "U" date type field; Inhalation Guinea pig TCLo 61 mg/m3/90D-C TXAPA9 10,270,1967

Hepatitis (hepatocellular necrosis), diffuse; Death in the "U" date type field; Inhalation Guinea pig TCLo 100 ppm/7H/33W-I AMIHBC 6,50,1952

Fatty liver degeneration; Kidney, Ureter, Bladder--Other changes; Endocrine--Other changes; Inhalation Guinea pig TCLo 25 ppm/8H/46W-I JIHTAB 18,277,1936

REVIEWS:

ACGIH TLV-Suspected human carcinogen DTLVS* TLV/BEI,1997

ACGIH TLV-STEL 63 mg/m3 (10 ppm) (skin) DTLVS* TLV/BEI,1997

ACGIH TLV-TWA 31 mg/m3 (5 ppm) DTLVS* TLV/BEI,1997

IARC Cancer Review:Animal Sufficient Evidence IMEMDT 20,371,1979

IARC Cancer Review:Animal Sufficient Evidence IMEMDT 1,53,1972

IARC Cancer Review:Human Inadequate Evidence IMEMDT 1,53,1972

IARC Cancer Review:Human Inadequate Evidence IMEMDT 20,371,1979

IARC Cancer Review:Group 2B IMSUDL 7,143,1987

TOXICOLOGY REVIEW ARZNAD 24,173,1974

TOXICOLOGY REVIEW 32XPAD -,49,1975

TOXICOLOGY REVIEW PAREAQ 4,1,1952

TOXICOLOGY REVIEW AJMEAZ 38,409,1965

TOXICOLOGY REVIEW BNYMAM 54,413,1978

TOXICOLOGY REVIEW CTOXAO 13,231,1978

TOXICOLOGY REVIEW 85CVA2 5,250,1970

TOXICOLOGY REVIEW CRTXB2 7,177,1980

TOXICOLOGY REVIEW JTEHD6 6,1133,1980

TOXICOLOGY REVIEW NTIS** PB256-732

STANDARDS AND REGULATIONS:

DOT-HAZARD 6.1; LABEL:POISON CFRGBR 49,172.101,1992

MSHA STANDARD-air TWA 10 ppm (65 mg/m3) (skin) DTLVS* 3,43,1971

OSHA PEL (Gen Indu) 8H TWA 10 ppm;CL 25 ppm;Pk 200 ppm/5M/4H CFRGBR 29,1910.1000,1994

OSHA PEL (Construc) 8H TWA 10 ppm (65 mg/m3) (skin) CFRGBR 29,1926.55,1994

OSHA PEL (Shipyard) 8H TWA 10 ppm (65 mg/m3) (skin) CFRGBR 29,1915.1000,1993

OSHA PEL (Fed Cont) 8H TWA 10 ppm (65 mg/m3) (skin) CFRGBR 41,50-204.50,1994

OEL-ARAB Republic of Egypt TWA 5 ppm (30 mg/m3);Skin JAN 1993

OEL-AUSTRALIA TWA 5 ppm (30 mg/m3);Skin;Carcinogen JAN 1993

OEL-BELGIUM TWA 5 ppm (31 mg/m3);Skin;Carcinogen JAN 1993

OEL-DENMARK TWA 2 ppm (13 mg/m3);Skin JAN 1993

OEL-FINLAND TWA 5 ppm (31 mg/m3);STEL 10 ppm (63 mg/m3);Skin;Carcinoge n JAN 1993

OEL-FRANCE TWA 2 ppm (12 mg/m3);STEL 10 ppm (60 mg/m3) JAN 1993

OEL-GERMANY TWA 10 ppm (65 mg/m3);Skin;Carcinogen JAN 1993

OEL-HUNGARY STEL 10 mg/m3;Skin;Carcinogen JAN 1993

OEL-INDIA TWA 5 ppm (30 mg/m3);Skin;Carcinogen JAN 1993

OEL-JAPAN TWA 10 ppm (63 mg/m3);Skin;Carcinogen JAN 1993

OEL-THE NETHERLANDS TWA 2 ppm (12.6 mg/m3);Skin JAN 1993

OEL-THE PHILIPPINES TWA 10 ppm (65 mg/m3);Skin JAN 1993

OEL-POLAND TWA 20 mg/m3 JAN 1993

OEL-RUSSIA TWA 10 ppm;STEL 20 mg/m3 JAN 1993

OEL-SWEDEN TWA 2 ppm (13 mg/m3);STEL 3 ppm (19 mg/m3);Skin;Carcinogen JAN 1993

OEL-SWITZERLAND TWA 5 ppm (30 mg/m3);STEL 10 ppm (60 mg/m3);Skin JAN 1993

OEL-THAILAND TWA 10 ppm;STEL 25 ppm JAN 1993

OEL-UNITED KINGDOM TWA 10 ppm (65 mg/m3);STEL 20 ppm;Skin JAN 1993

OEL IN BULGARIA COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND SINGAPORE, VIETNAM check ACGIH TLV

NIOSH CRITERIA DOCUMENTS:

NIOSH REL TO CARBON TETRACHLORIDE air:CA STEL 2 ppm/60M NIOSH* DHHS #92-100,1992

NOHS 1974: HZD 17490; NIS 73; TNF 5152; NOS 56; TNE 64009

NOES 1983: HZD 17490; NIS 77; TNF 6629; NOS 72; TNE 104174; TFE 20699

NTP, NIOSH, EPA STATUS:

ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/168196/AS)

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Scerevisiae gene conversion

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis; Scerevisiae-reversion

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm morphology-mouse

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, SEPTEMBER 1997

NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003

NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen

IRRITATION EFFECTS JOURNAL REFERENCES:

XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Rochester, NY

85JCAE Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986

MUTATION EFFECTS JOURNAL REFERENCES:

CRNGDP Carcinogenesis (London). Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK V.1- 1980-

EJMBA2 Egyptian Journal of Microbiology. National Information and Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt V.7- 1972-

ENMUDM Environmental Mutagenesis. New York, NY V.1-9, 1979-87. For publisher information, see EMMUEG.

FHCYAI Folia Histochemica et Cytochemica. Cracow, Poland V.1-21, 1963-83.

IJCNAW International Journal of Cancer. International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland V.1- 1966-

MUREAV Mutation Research. Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands V.1- 1964-

PAACA3 Proceedings of the American Association for Cancer Research. Waverly Press, 428 E. Preston St., Baltimore, MD 21202 V.1- 1954-

PSEBAA Proceedings of the Society for Experimental Biology and Medicine. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1903/04-

SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982

TOLED5 Toxicology Letters. Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands V.1- 1977-

REPRODUCTIVE EFFECTS JOURNAL REFERENCES:

BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. Plenum Pub. Corp., 233 Spring St., New York, NY 10013 V.41- 1956-

DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106 V.30- 1969-

EXPEAM Experientia. Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland V.1- 1945-

TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959-

TXCYAC Toxicology. Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland V.1- 1973-

85DJA5 Malformations Congenitales des Mammiferes, Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971

TUMORIGENIC EFFECTS JOURNAL REFERENCES:

BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. Plenum Pub. Corp., 233 Spring St., New York, NY 10013 V.41- 1956-

JNCIAM Journal of the National Cancer Institute. Washington, DC V.1-60, 1940-78. For publisher information, see JJIND8.

KRMJAC Kurume Medical Journal. Kurume Univ. School of Medicine, Dept. of Physiology, 67, Asahi- machi, Kurume 830, Japan V.1- 1954-

TOXICITY EFFECTS JOURNAL REFERENCES:

AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. Leipzig, Ger. Dem. Rep. V.1-109, 1873-1925. For publisher information, see NSAPCC.

ARTODN Archives of Toxicology. Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger. V.32- 1974-

ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128 V.1- 1990-

BVJOA9 British Veterinary Journal. Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK V.105- 1949-

FLCRAP Fluorine Chemistry Reviews. Marcel Dekker, 270 Madison Ave., New York, NY 10016 V.1- 1967-

GASTAB Gastroenterology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1943-

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1- 1936-

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1-36, 1957-1992. For publisher information, see MTPEEI

HBAMAK Abdernalden's Handbuch der Biologischen Arbeitsmethoden. (Leipzig, Ger. Dem. Rep.)

JAMAAP JAMA, Journal of the American Medical Association. AMA, 535 N. Dearborn St., Chicago, IL 60610 V.1- 1883-

JIHTAB Journal of Industrial Hygiene and Toxicology. Cambridge, MA V.18-31, 1936-49. For publisher information, see AEHLAU.

JPETAB Journal of Pharmacology and Experimental Therapeutics. Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202 V.1- 1909/10-

JPPMAB Journal of Pharmacy and Pharmacology. Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK V.1- 1949-

LANCAO Lancet. 7 Adam St., London WC2N 6AD, UK V.1- 1823-

NIHBAZ National Institutes of Health, Bulletin. Bethesda, MD

NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.

National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015

NTIS** National Technical Information Service. Springfield, VA 22161 Formerly U.S. Clearinghouse for Scientific & Technical Information.

PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Topeka, KS

PHMCAA Pharmacologist. American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014 V.1- 1959-

QJPPAL Quarterly Journal of Pharmacy & Pharmacology. London, UK V.2-21, 1929-48. For publisher information, see JPPMAB.

SAMJAF South African Medical Journal. Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa V.6- 1932-

SPEADM Special Publication of the Entomological Society of America. 4603 Calvert Rd., College Park, MD 20740

TABIA2 Tabulae Biologicae. The Hague, Netherlands V.1-22, 1925-63. Discontinued.

TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959-

TXMDAX Texas Medicine. Texas Medical Assoc., 1801 N. Lamar Blvd., Austin, TX 78701 V.60- 1964-

XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Rochester, NY

ZAPPAN Zentralblatt fuer Allgemeine Pathologie und Pathologische Anatomie. VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep. V.1- 1890-

ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep. V.1- 1955-

85CYAB Chemistry of Industrial Toxicology, 2nd ed., Elkins, H.B., New York, John Wiley & Sons, Inc., 1959

85DCAI Poisoning; Toxicology, Symptoms, Treatments, 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970

OTHER MULTIPLE DOSE EFFECTS JOURNAL REFERENCES:

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. Chicago, IL V.2-10, 1950-54. For publisher information, see AEHLAU.

ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50 3, 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.

FAATDF Fundamental and Applied Toxicology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1981-

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1-36, 1957-1992. For publisher information, see MTPEEI

INHEAO Industrial Health. National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan V.1- 1963-

JIHTAB Journal of Industrial Hygiene and Toxicology. Cambridge, MA V.18-31, 1936-49. For publisher information, see AEHLAU.

JPETAB Journal of Pharmacology and Experimental Therapeutics. Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202 V.1- 1909/10-

JPPMAB Journal of Pharmacy and Pharmacology. Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK V.1- 1949-

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.

Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Izdatel'stvo Meditsina, Moscow, USSR No.1- 1961-

TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959-

REVIEWS JOURNAL REFERENCES:

AJMEAZ American Journal of Medicine. Technical Pub., 875 Third Ave., New York, NY 10022 V.1- 1946-

ARZNAD Arzneimittel-Forschung. Drug Research. Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger. V.1- 1951-

BNYMAM Bulletin of the New York Academy of Medicine. New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029 Ser 2: V.1- 1925-

CRTXB2 CRC Critical Reviews in Toxicology. CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431 V.1- 1971-

CTOXAO Clinical Toxicology. New York, NY V.1-18, 1968-81. For publisher information, see JTCTDW.

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists ACGIH, Cincinnati, OH, 1996

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210 V.1- 1972-

IMSUDL IARC Monographs, Supplement. WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210 No.1- 1979-

JTEHD6 Journal of Toxicology and Environmental Health. Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005 V.1- 1975/76-

NTIS** National Technical Information Service. Springfield, VA 22161 Formerly U.S. Clearinghouse for Scientific & Technical Information.

PAREAQ Pharmacological Reviews. Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202 V.1- 1949-

32XPAD Teratology, Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975

85CVA2 Oncology 1970, Proceedings of the Tenth International Cancer Congress, Chicago, Year Book Medical Pub., 1971

STANDARDS & REGULATIONS JOURNAL REFERENCES:

CFRGBR Code of Federal Regulations. U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996

DATA PRESENT: Irritation Effects; Mutation Effects; Reproductive Effects; Tumorigenic Effects; Toxicity Effects; Human Toxicity Effects; Other Multiple Dose Effects; Reviews; Standards and Regulations; NIOSH Criteria Documents; NTP, NIOSH, EPA Status

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