Molecular Formula: CHClF2
Molecular Weight: 86.47

Beilstein Registry Number: 1731036
Beilstein Source Citation: 4-01-00-00032

Synonyms: Algeon 22; Algofrene 22; Algofrene type 6; Arcton 4; Arcton 22; CFC 22; Chlorodifluoromethane (ACGIH:DOT); Daiflon 22; Difluorochloromethane; Difluoromonochloromethane; Dymel 22; Electro-CF 22; Eskimon 22; F 22; Flugene 22; Fluorocarbon-22; Forane 22; Freon 22; Frigen 22; Genetron 22; Haltron 22; HFA-22; Isceon 22; Isotron 22; Khaladon 22; Monochlorodifluoromethane; Propellant 22; R-22; R22 (DOT); R 22 (refrigerant); Racon 22; Refrigerant R 22; Ucon 22; UN1018 (DOT)

Compound Class: Tumorigen; Mutagen; Reproductive Effector
Wiswesser Line Notation: GYFF
Record Date: 199712

MUTATION DATA:

Mutation in microorganisms Salmonella typhimurium 33 pph/24H-C TOLED5 2,1,1978

REPRODUCTIVE EFFECTS DATA:

Prostate, seminal vessicle, Cowper's gland, accessory glands Inhalation Rat TCLo 50000 ppm/5H 56D male FAATDF 1,266,1981

Developmental Abnormalities: Eye, ear Inhalation Rat TCLo 5 ppm 6-15D preg NTIS** OTS0520838

TOXICITY EFFECTS DATA:

Altered sleep time;Ataxia;Respiratory depression Inhalation Rat LC50 35 pph/15M HUTODJ 1,239,1982

Somnolence (general depressed activity);Ataxia;Cyanosis Inhalation Mouse LC50 1380 mg/m3/2H TLSMA6 75,241,1963

Lungs, Thorax, or Respiration--Other changes Inhalation Dog LCLo 70 pph TXAPA9 2,363,1960

General anesthetic;Somnolence (general depressed activity);Convulsions or effect on seizure threshold Inhalation Guinea pig LCLo 30 pph/2H ZAARAM 21,149,1971

OTHER MULTIPLE DOSE EFFECTS DATA:

Brain and Coverings--Other degenerative changes; Changes in other cell count (unspecified); Weight loss or decreased weight gain; Oral Rat TDLo 2457 mg/kg/26W-I GISAAA 48(8),69,1983

Brain and Coverings--Other degenerative changes; Spinal Cord--Other degenerative changes; Alteration of classical conditioning; Inhalation Mouse TCLo 50 gm/m3/6H/43W-I TLSMA6 75,231,1963

REVIEWS:

ACGIH TLV-Not classifiable as a human carcinogen DTLVS* TLV/BEI,1997

ACGIH TLV-TWA 3540 mg/m3 (1000 ppm) DTLVS* TLV/BEI,1997

IARC Cancer Review:Animal Limited Evidence IMEMDT 41,237,1986

IARC Cancer Review:Human Inadequate Evidence IMEMDT 41,237,1986

IARC Cancer Review:Group 3 IMSUDL 7,149,1987

TOXICOLOGY REVIEW FAZMAE 18,365,1974

TOXICOLOGY REVIEW NYSJAM 74,1939,1974

STANDARDS AND REGULATIONS:

DOT-HAZARD 2.2; LABEL:NONFLAMMABLE GAS CFRGBR 49,172.101,1992

OEL-AUSTRALIA TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993

OEL-AUSTRIA TWA 500 ppm (1800 mg/m3) JAN 1993

OEL-BELGIUM TWA 1000 ppm (3540 mg/m3);STEL 1250 ppm JAN 1993

OEL-DENMARK TWA 1000 ppm (3500 mg/m3) JAN 1993

OEL-FINLAND TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993

OEL-FRANCE TWA 1000 ppm (3500 mg/m3) JAN 1993

OEL-GERMANY TWA 500 ppm (1800 mg/m3) JAN 1993

OEL-HUNGARY TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993

OEL-JAPAN TWA 1000 ppm (3500 mg/m3) JAN 1993

OEL-THE NETHERLANDS TWA 1000 ppm (3500 mg/m3) JAN 1993

OEL-RUSSIA TWA 1000 ppm;STEL 3000 mg/m3 JAN 1993

OEL-SWEDEN TWA 500 ppm (1800 mg/m3);STEL 750 ppm (2500 mg/m3) JAN 1993

OEL-SWITZERLAND TWA 500 ppm (1800 mg/m3) JAN 1993

OEL-UNITED KINGDOM TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993

OEL IN BULGARIA COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND SINGAPORE, VIETNAM check ACGIH TLV

NIOSH CRITERIA DOCUMENTS:

NIOSH REL TO CHLORODIFLUOROMETHANE air:TWA 1000 ppm;STEL 1250 ppm NIOSH* DHHS #92-100,1992

NOHS 1974: HZD 80048; NIS 76; TNF 7420; NOS 44; TNE 56234

NOES 1983: HZD 80048; NIS 78; TNF 12513; NOS 57; TNE 157080; TFE 12185

NTP, NIOSH, EPA STATUS:

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9099;8EHQ-0892-9107

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9108;8EHQ-0892-9117

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9118

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, SEPTEMBER 1997

NIOSH Analytical Method, 1994: Chlorodifluoromethane, 1018

MUTATION EFFECTS JOURNAL REFERENCES:

TOLED5 Toxicology Letters. Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands V.1- 1977-

REPRODUCTIVE EFFECTS JOURNAL REFERENCES:

FAATDF Fundamental and Applied Toxicology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1981-

NTIS** National Technical Information Service. Springfield, VA 22161 Formerly U.S. Clearinghouse for Scientific & Technical Information.

TOXICITY EFFECTS JOURNAL REFERENCES:

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1- 1936-

HUTODJ Human Toxicology. Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK V.1- 1981-

TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Leningrad, Russia V.1-145, 1949-82. Discontinued.

TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959-

ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Darmstadt, Fed. Rep. Ger. V.1-25, 1951-75.

OTHER MULTIPLE DOSE EFFECTS JOURNAL REFERENCES:

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1- 1936-

TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Leningrad, Russia V.1-145, 1949-82. Discontinued.

REVIEWS JOURNAL REFERENCES:

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996

FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094 V.1- 1959-

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210 V.1- 1972-

IMSUDL IARC Monographs, Supplement. WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210 No.1- 1979-

NYSJAM New York State Journal of Medicine. Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042 V.1- 1901-

STANDARDS & REGULATIONS JOURNAL REFERENCES:

CFRGBR Code of Federal Regulations. U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402

DATA PRESENT: Mutation Effects; Reproductive Effects; Toxicity Effects; Other Multiple Dose Effects; Reviews; Standards and Regulations; NIOSH Criteria Documents; NTP, NIOSH, EPA Status

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