CN Medical and Chemical Analysis

Acetophenone, 2-chloro- (CN)

CAS Registry Number: 532-27-4
Substance Name: Acetophenone, 2-chloro- (CN)Molecular Formula: C8H7ClO
Molecular Weight: 154.60Synonyms: Chemical mace ; alpha-Chloroacetophenone ; omega-Chloroacetophenone ; 2-Chloroacetophenone ; alpha-Chloroacetophenone (ACGIH:OSHA) ; Chloromethyl phenyl ketone ; 2-Chloro-1-phenylethanone ; CN ; Ethanone, 2-chloro-1-phenyl- ; Mace (lacrimator) ; NCI-C55107 ; Phenacyl chloride ; Phenylchloromethylketone
Compound Class: Tumorigen; Mutagen; Human Data; Primary Irritant

IRRITATION DATA:

RTSPDOEFCDVOPG	PY
sknrat12 %/6H openMODARTODN4075	1978
sknrbt5 mg/24HMLDTXAPA917295	1970
sknrbt12 %/6H openMODARTODN4075	1978
eyerbt1 mgMLDTXAPA917295	1970
eyerbt3 mgSEVTXAPA917295	1970
skngpg12 %/6H openMODARTODN4075	1978

MUTATION DATA:

TSSPCTRTDOCDVORG	PY
dndratlvr10 umol/LMUREAV36859	1996
cythamovr3 mg/LNTPTR*NTP-TR-379	1990

TUMORIGENIC EFFECTS DATA:

EFRTSPTYDOCDVOPG	PY
V03;N60;R60ihlratTCLo2 mg/m3/6H/2Y-INTPTR*NTP-TR-379	1990
V02;R60;V10sknmusTDLo2400 mg/kg/27W-IBJCAAI7482	1953

TOXICITY EFFECTS DATA:

EFRTSPTYDOCDVOPG	PY
*ihlhmnLCLo159 mg/m3/20M34ZIAG -163	1969
D17;D25;J22ihlhmnLCLo93 mg/m3/3MAIHAAP23199	1962
D35;D21;J22ihlhmnLCLo20 mg/m3BJIMAG29298	1972
*orlratLD5050 mg/kgTXAPA917295	1970
D07;J15;P01ihlratLCLo417 mg/m3/15MARTODN4075	1978
F24;J30;R21iprratLD5036 mg/kgARTODN4075	1978
F12;J26;M30ivnratLD5041 mg/kgARTODN4075	1978
orlmusLD50139 mg/kgNTIS*AD837-111
*ihlmusLC5059 mg/m3GISAAA58(10)4	1993
iprmusLC5060 mg/kgNTIS*AD837-111
F12;J26;M30ivnmusLD5081 mg/kgARTODN4075	1978
F24;J30;R21orlrbtLD50118 mg/kgARTODN4075	1978
D07;J15;P01ihlrbtLDLo465 mg/m3/20MARTODN4075	1978
F12;J26;M30ivnrbtLD5030 mg/kgARTODN4075	1978
F24;J30;R21orlgpgLD50158 mg/kgARTODN4075	1978
D07;J15;P01ihlgpgLDLo490 mg/m3/30MARTODN4075	1978
F24;J30;R21iprgpgLD5017 mg/kgARTODN4075	1978

OTHER MULTIPLE DOSE EFFECTS DATA:

EFRTSPTYDOCDVOPG	PY
Z01ihlratTCLo19 mg/m3/6H/14D-INTPTR*NTP-TR-379	1990
Z01ihlmusTCLo10 mg/m3/6H/14D-INTPTR*NTP-TR-379	1990

REVIEWS:

ACGIH TLV-Not classifiable as a human carcinogen DTLVS* TLV/BEI,1997 ACGIH TLV-TWA 0.32 mg/m3 (0.05 ppm) DTLVS* TLV/BEI,1997

STANDARDS AND REGULATIONS:

MSHASTANDARD-airTWA0.05 ppm(0.3 mg/m3)DTLVS*348	1971
OSHAPEL (Gen Indu)8HTWA0.05 ppm(0.3 mg/m3)CFRGBR291910.1000	1994
OSHAPEL (Construc)8HTWA0.05 ppm(0.3 mg/m3)CFRGBR291926.55	1994
OSHAPEL (Shipyard)8HTWA0.05 ppm(0.3 mg/m3)CFRGBR291915.1000	1993
OSHAPEL (Fed Cont)8HTWA0.05 ppm(0.3 mg/m3)CFRGBR4150-204.50	1994
OEL-AUSTRALIATWA0.05 ppm(0.3 mg/m3)	JAN 1993
OEL-AUSTRIAMAK0.05 ppm(0.3 mg/m3)	JAN 1999
OEL-BELGIUMTWA0.05 ppm(0.32 mg/m3)	JAN 1993
OEL-DENMARKTWA0.05 ppm(0.3 mg/m3)	JAN 1999
OEL-FINLANDSTEL0.05 ppm(0.3 mg/m3);Skin	JAN 1993
OEL-THE NETHERLANDSTWA0.05 ppm(0.3 mg/m3)	JAN 1993
OEL-THE PHILIPPINESTWA0.05 ppm(0.3 mg/m3)	JAN 1993
OEL-SWITZERLANDTWA0.05 ppm(0.3 mg/m3)	JAN 1993
OEL-UNITED KINGDOMTWA0.05 ppm(0.3 mg/m3)	JAN 1993
OELIN BULGARIACOLOMBIAJORDANKOREAcheckACGIH	TLV
OELIN NEW ZEALANDSINGAPOREVIETNAMcheckACGIH	TLV

NIOSH CRITERIA DOCUMENTS: NIOSH REL TO alpha CHLOROACETOPHENONE-air:10H TWA 0.05 ppm NIOSH* DHHS #92-100,1992
NOES 1983: HZD X4754; NIS 1; TNF 35; NOS 4; TNE 2294; TFE 1412

NTP, NIOSH, EPA STATUS: EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies On EPA IRIS database EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, SEPTEMBER 1999 NTP Carcinogenesis Studies (inhalation);equivocal evidence:rat NTPTR* NTP-TR-379,1990NTP Carcinogenesis Studies (inhalation);no evidence:mouse NTPTR* NTP-TR-379,1990

IRRITATION EFFECTS JOURNAL REFERENCES: ARTODN Archives of Toxicology. Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger. V.32- 1974- TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959-

MUTATION EFFECTS JOURNAL REFERENCES: MUREAV Mutation Research. Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands V.1- 1964- NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206-

TUMORIGENIC EFFECTS JOURNAL REFERENCES: BJCAAI British Journal of Cancer. Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK V.1- 1947- NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206-

TOXICITY EFFECTS JOURNAL REFERENCES: AIHAAP American Industrial Hygiene Association Journal. AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311 V.19- 1958- ARTODN Archives of Toxicology. Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger. V.32- 1974- BJIMAG British Journal of Industrial Medicine. British Medical Journal, Box 560B, Kennebunkport, ME 04046 V.1- 1944- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR V.1- 1936- NTIS** National Technical Information Service. Springfield, VA 22161 Formerly U.S. Clearinghouse for Scientific & Technical Information. TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959- 34ZIAG Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969

OTHER MULTIPLE DOSE EFFECTS JOURNAL REFERENCES: NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206-

REVIEWS JOURNAL REFERENCES: DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996

STANDARDS & REGULATIONS JOURNAL REFERENCES: CFRGBR Code of Federal Regulations. U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996

NIOSH CRITERIA DOCUMENTS JOURNAL REFERENCES:NTP, NIOSH, EPA STATUS JOURNAL REFERENCES:
NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206-

DATA PRESENT: Irritation Effects; Mutation Effects; Tumorigenic Effects; Toxicity Effects; Human Toxicity Effects; Other Multiple Dose Effects; Reviews; Standards and Regulations; NIOSH Criteria Documents; NTP, NIOSH, EPA Status