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CAS Registry Number: 2698-41-1 Substance Name: Malononitrile, o-chlorobenzylidene- (CS) Molecular Formula: C10H5ClN2 Molecular Weight: 188.62 Synonyms: (o-Chlorobenzal)malononitrile ; 2-Chlorobenzalmalononitrile ; o-Chlorobenzylidene malonitrile ; 2-Chlorobenzylidene malononitrile ; o-Chlorobenzylidene malononitrile (ACGIH:OSHA) ; 2-Chlorobmn ; CS ; beta,beta-Dicyano-o-chlorostyrene ; NCI-C55118 ; Propanedinitrile, ((2-chlorophenyl)methylene) ; USAF KF-11 ; TL 238 Compound Class: Tumorigen; Mutagen; Reproductive Effector; Human Data; Primary Irritant IRRITATION DATA:
MUTATION DATA: Mutation in microorganisms Salmonella typhimurium 100 ug/plate
ARTODN 49,15,1981Mutation in mammalian somatic cells Mouse Lymphocyte 2500 ug/L
EMMUEG 11,91,1988Micronucleus test Hamster Lung 19 umol/L ARTODN 63,314,1989 REPRODUCTIVE EFFECTS DATA: Fetotoxicity (except death) Inhalation Rat TCLo 6 mg/m3/5M 6-15D preg 37QLAZ -,79,1977 TOXICITY EFFECTS DATA: Conjunctive irritation ;Cough ;Lungs, Thorax, or Respiration--Other
changes Inhalation Human TCLo 1500 ug/m3/90M AEHLAU 6,366,1963Gastritis Oral Rat LD50 178 mg/kg AEHLAU 24,449,1972
Convulsions or effect on seizure threshold ;Respiratory stimulation ;Kidney, Ureter, Bladder--Other changes Intravenous Rat LD50 28 mg/kg ARTODN 40,75,1978
Olfaction--Other ;Acute pulmonary edema ;Hemorrhage Inhalation Mouse LCLo 2753 mg/m3/20M ARTODN 40,75,1978Decrease in humoral immune response Intraperitoneal Mouse LD50 32320 ug/kg TOLED5 8,73,1981
Convulsions or effect on seizure threshold ;Lungs, Thorax, or Respiration--Other changes Intravenous Mouse LD50 47700 ug/kg TXAPA9 25,111,1973Lungs, Thorax, or Respiration--Other changes Inhalation Dog LCLo 2600 mg/m3/23M FEPRA7 30(1),86,1971Coma ;Lungs, Thorax, or Respiration--Other changes ;Hair Oral Rabbit LD50 143 mg/kg ARTODN 40,75,1978Olfaction--Other ;Acute pulmonary edema ;Hemorrhage Inhalation Rabbit LCLo 1802 mg/m3/10M ARTODN 40,75,1978Blood--Other changes Intraperitoneal Rabbit LD50 32065 ug/kg TOXID9 3,64,1983Lacrimation ;Somnolence (general depressed activity) ;Hypermotility, diarrhea Intravenous Rabbit LD50 8 mg/kg TXAPA9 4,656,1962Coma ;Lungs, Thorax, or Respiration--Other changes ;Hair Oral Guinea pig LD50 212 mg/kg ARTODN 40,75,1978Olfaction--Other ;Acute pulmonary edema ;Hemorrhage Inhalation Guinea pig LCLo 2326 mg/m3/10M ARTODN 40,75,1978Coma ;Lungs, Thorax, or Respiration--Other changes ;Hair Intraperitoneal Guinea pig LD50 73 mg/kg ARTODN 40,75,1978 OTHER MULTIPLE DOSE EFFECTS DATA: Lacrimation ; Death in the "U" date type field ; Inhalation Rat TCLo 100 mg/m3/6H/14D-I NTPTR* NTP-TR-377,1990Olfaction--Other ; Changes in thymus weight ; Weight loss or decreased weight gain ; Inhalation Rat TCLo 1500 ug/m3/6H/13W-I NTPTR* NTP-TR-377,1990Death in the "U" date type field ; Inhalation Mouse TCLo 10 mg/m3/6H/14D-I NTPTR* NTP-TR-377,1990Olfaction--Other ; Weight loss or decreased weight gain ; Death in the "U" date type field ; Inhalation Mouse TCLo 3 mg/m3/6H/13W-I NTPTR* NTP-TR-377,1990Changes in liver weight ; Changes in thymus weight ; Decrease in humoral immune response ; Intraperitoneal Mouse TDLo 160 mg/kg/10D-I BECTA6 26,571,1981 REVIEWS: ACGIH TLV-Not classifiable as a human carcinogen DTLVS* TLV/BEI,1997 STANDARDS AND REGULATIONS:
NIOSH CRITERIA DOCUMENTS: NIOSH REL TO o CHLOROBENZYLIDENEMALONONITRILE-air:CL 0.05 ppm (Sk) NIOSH* DHHS #92-100,1992 NTP, NIOSH, EPA STATUS: EPA TSCA Section 8(b) CHEMICAL INVENTORY IRRITATION EFFECTS JOURNAL REFERENCES: APTOA6 Acta Pharmacologica et Toxicologica. Copenhagen, Denmark V.1-59, 1945-86. For publisher information, see PHTOEHARTODN Archives of Toxicology. Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger. V.32- 1974-BJDEAZ British Journal of Dermatology. Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK V.63- 1951-MMEDA9 Military Medicine. Assoc. of Military Surgeons of the United States, Box 104, Kensington, MD 20795 V.116- 1955-TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959- MUTATION EFFECTS JOURNAL REFERENCES: ARTODN Archives of Toxicology. Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger. V.32- 1974-EMMUEG Environmental and Molecular Mutagenesis. Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003 V.10- 1987-MUREAV Mutation Research. Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands V.1- 1964-NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206- REPRODUCTIVE EFFECTS JOURNAL REFERENCES: 37QLAZ Current Approaches in Toxicology, Ballantyne, B., ed., Bristol, UK, John Wright & Sons, Ltd., 1977 TOXICITY EFFECTS JOURNAL REFERENCES: AEHLAU Archives of Environmental Health. Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016 V.1- 1960-ARTODN Archives of Toxicology. Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger. V.32- 1974-FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. Bethesda, MD V.1-46, 1942-87.NTIS** National Technical Information Service. Springfield, VA 22161 Formerly U.S. Clearinghouse for Scientific & Technical Information.TOLED5 Toxicology Letters. Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands V.1- 1977-TOXID9 Toxicologist. Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311 V.1- 1981-TXAPA9 Toxicology and Applied Pharmacology. Academic Press, Inc., 1 E. First St., Duluth, MN 55802 V.1- 1959- OTHER MULTIPLE DOSE EFFECTS JOURNAL REFERENCES: BECTA6 Bulletin of Environmental Contamination and Toxicology. Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094 V.1- 1966-NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206- REVIEWS JOURNAL REFERENCES: DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996 STANDARDS & REGULATIONS JOURNAL REFERENCES: CFRGBR Code of Federal Regulations. U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists ACGIH, Cincinnati, OH, 1996 NIOSH CRITERIA DOCUMENTS JOURNAL REFERENCES: NTP, NIOSH, EPA STATUS JOURNAL REFERENCES: NTPTR* National Toxicology Program Technical Report Series. Research Triangle Park, NC 27709 No.206- DATA PRESENT: Irritation Effects; Mutation Effects; Reproductive Effects; Toxicity Effects; Human Toxicity Effects; Other Multiple Dose Effects; Reviews; Standards and Regulations; NIOSH Criteria Documents; NTP, NIOSH, EPA Status
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